Orisme W, Goldmann T, McDowell JH, Li J, Wolfrum U, Smith CW (2009) Light-dependent translocation of arrestin in rod photoreceptors is signaled through a phospholipase C cascade and requires ATP. (in prep.).
Chakarova Cf, Khanna H, Shah AZ, Papaioannou MG, Nagel-Wolfrum K, Sedmak T, Lopez I, Munro P, Cheetham M, Matter K, Wolfrum U, Koenekoop RK, Swaroop A, Bhattacharya SS (2009) TOPORS, which is mutated in retinal degeneration is a novel ciliary component of photoreceptors and associates with structural maintenance of chromosomes (SMC) proteins and the microtubule motor complex. (in prep.).
Rausch S, Gießl A, Hildebrand PW, Wolfrum U, Pulvermüller A (2009) Interaction sites of centrin-transducin complexes. (in prep.) (*both authors contributed equally to the work).
Sedmak T, Latz M, Keady B, Pazour GJ, Wolfrum U (2009) Differential ciliary and non-ciliary localization of IFT molecules in mammalian retina. (in prep.)
Insinna C, Humby M, Sedmak T, Wolfrum U, Besharse JC (2009) Different roles for KIF17 and kinesin II in photoreceptor development and maintenance. (submitted)
Jaissle GB, May CA, van de Pavert S, Wenzel A, Claes E, Reidel B, Szurman P, Haverkamp S, Fischer MD, Wolfrum U, Wijnholds J, Remé CE, Lütjen-Drecoll E, Humphries P, Seeliger MW (2009) Bone spicule formation in retinitis pigmentosa: Insights from a mouse model. (submitted to IOVS).
Goldmann T, Rebibo-Sabbah A, Overlack N, Nudelman I, Balakhov V, Baasov T, Ben-Yosef T, Wolfrum U, Nagel-Wolfrum K (2009) The potential of aminoglycoside mediated gene based therapy of Usher syndrome 1C (under review by Gene Therapy).
Gamerdinger M, Hajieva P, Kaya AM, Wolfrum U, Hartl, FU, Behl C (2009) Protein quality control during aging involves recruitement of the macroautophagy pathway by BAG3. EMBO J 2009 Feb 19. (Epub ahead of print).
Thissen MC, Trojan P, Krieglstein J, Wolfrum U*, Klumpp S* (2008) Selective dephosphorylation of a specific CK2 phosphorylation site of centrin 1 by protein phosphatase type 2Cß. (under review by FEBS Letters) (*both senior authors contributed equally to the work).
Schneider E, Märker T, Daser A, Frey-Mahn G, Beyer V, Farcas R, Schneider-Rätzke B, Kohlschmidt N, Grossmann B, Bauß K, Napiontek U, Keilmann A, Bartsch O, Zechner U, Wolfrum U, Haaf T (2009) Homozygous disruption of PDZD7 by reciprocal translocation in a consanguineous family: a new member of the Usher syndrome protein interactome causing congenital hearing impairment. Hum Mol Genet 18:655-666.
Specht D, Wu S-B, Turner P, Dearden P, Koentgen F, Maw M, Wolfrum U, Brandstätter JH, tom Dieck S (2009) Effects of presynaptic mutations on a postsynaptic Cacna1s calcium channel colocalized with mGluR6 at mouse photoreceptor ribbon synapses. Invest Ophthalmol Visual Sci 50:505-515.
van Wijk E, Kersten FF, Kartono A, Mans DA, Brandwijk K, Letteboer SJ, Peters TA, Märker T, Yan X, Cremers CW, Cremers F, Wolfrum U, Roepman R, Kremer H (2008) Usher syndrome and Leber congenital amaurosis are molecularly linked via a novel isoform of the centrosomal ninein-like protein. Hum Mol Genet 18:51-64.
Reidel B, Goldmann T, Gießl A, Wolfrum U (2008) The translocation of signaling molecules in dark adapting mammalian rod photoreceptor cells are dependent on the cytoskeleton. Cell Motil Cytoskeleton 65:785-800.
Feiden S, Wolfrum U, Wegener G, Kamp G (2008) Expression and compartmentalisation of the glycotic enzymes GAPDH and pyruvate kunase in boar spermatogenesis. Reprod Fertil Dev 20:713-723.
Spiwoks-Becker I, Maus C, tom Dieck S, Fejtová A, Engel L, Wolloscheck T, Wolfrum U, Vollrath, Spessert R (2008) Active zone proteins are dynamically associated with synaptic ribbons in rat pinealocytes. Cell Tissue Res 333:185-195.
Grube S, Wolfrum U, Langguth P (2008) Characterization of the epithelial permeation enhancing effect of basic butylated methacrylate copolymer - in vitro studies. Biomacromolecules 9:1398-1405.
Trojan P, Gießl A, Choe H-W, Krauß N, Pulvermüller A, Wolfrum U (2008) Centrin function in vertebrate photoreceptor cells. Prog in Retinal and Eye Res 27:237-259.
Trojan P*, Rausch S*, Gießl A, Klemm C, Krause E, Pulvermüller A§, Wolfrum U§ (2008) Light-dependent CKII-mediated phosphorylation regulates centrin-G-protein complex formation with retinal G-proteins. Biochim Biophys Acta - Mol Cell Res 1783:1248-1260. (both *first and §senior authors contributed equally to the work).
Lefèvre G, Michel V, Weil D, Lepelletier L, Bizard E, Wolfrum U, Hardelin JP, Petit C (2008) A cochlear core phenotype in USH1 mouse mutants implicates fibrous links of the hair bundle in its cohesion, orientation, and differential growth. Development 135:1427-1437.
Mersseman V, Böhm V, Holtappels R, Deegen P, Wolfrum U, Plachter B, Reyda S (2008) Refinement o strategies for the development of a human cytomegalovirus dense body vaccine. Med Microbiol Immunol 197:97-107.
Mersseman V, Besold K, Reddehase MJ, Wolfrum U, Strand D, Plachter B, Reyda S (2008) Exogenous introduction of an immunodominant peptide from the non-structural IE1 protein of human cytomegalovirus into the MHC class I presentation pathway by recombinant dense bodies. J Gen Virol 89:369-79.
Maerker T, van Wijk E, Overlack N, Kersten FFJ, McGee J, Goldmann T, Sehn E, Roepman R, Walsh EJ, Kremer H, Wolfrum U (2008) A novel Usher protein network at the periciliary reloading point between molecular transport machineries in vertebrate photoreceptor cells. Hum Mol Genet 17:71-86.
Overlack N*, Märker T*, Latz, M, Nagel-Wolfrum, K, Wolfrum U (2008) SANS (USH1G) expression in developing and mature mammalian retina. Vision Res 48:400-412. (*first authors contributed equally to the work)
Glube N, Gießl A, Wolfrum U, Langguth P (2007) Caki-1 cells represent an in vitro model system for studying the human proximal tubule epithelium. Nephron Exp Nephrol 107:e47-e56, Sep 5; [Epub ahead of print]
Feiden S, Stypa H, Wolfrum U, Wegener G, Kamp G. (2007) A novel pyruvate kinase (PK-S) from boar spermatozoa is localized at the fibrous sheath and the acrosome. Reproduction 134:81-95.
Gosens I, Van Wijk E, Kersten F, Krieger E, Van der Zwaag B, Märker T, Letteboer SJF, Dusseljee S, Peters T, Spierenburg HA, Punte IM, Wolfrum U, Cremers FPM, Kremer H, Roepman R (2007) MPP1 links the Usher protein network and the Crumbs protein complex in the retina. Hum Mol Genet 16:1993-2003.
Arts HH, Doherty D, van Beersum SEC, Parisi M, Letteboer SJF, Gorden NT, Peters TA, Märker T, Voesenek K, Kartono A, Ozyurek H, Farin FM, Kroes HY, Wolfrum U, Brunner HG, Cremers FPM, Glass IA, Knoers NVAM, Roepman R (2007) Mutations in the gene encoding the basal body protein KIAA1005, a novel nephrocystin-4 interactor, cause Joubert syndrome. Nat Genet 39:882-888.
den Hollander AI., Koenekoo RK, Mohamed MD, Arts HH, Boldt K, Towns KV, Sedmak T, Beer M, Nagel-Wolfrum K, McKibbin M, Dharmaraj S, Lopez I, Ivings L, Williams GA, Springell K, Woods CG, Jafri H, Rashid Y, Strom TM, van der Zwaag B, Gosens I, Kersten FFJ, van Wijk E, Veltman JA, Zonneveld MN, van Beersum SEC, Maumenee IH, Wolfrum U, Cheetham ME, Ueffing M, Cremers FPM, Inglehearn CF, Roepman R (2007) Mutations in LCA5, encoding the ciliary protein lebercilin, cause Leber congenital amaurosis. Nat Genet 39:889–895.
Hyenne V, Harf JC, Latz M, Maro B, Wolfrum U*, Simmler M-C* (2007) Vezatin, a ubiquitous protein of adherens cell-cell junctions, is exclusively expressed in germ cells in mouse testis. Reproduction 133:563-574 (*both senior authors contributed equally to the work).
Roepman, R and Wolfrum U (2007) Protein networks and complexes in photoreceptor cilia. In: Bertrand E and Faupel M and (eds) Subcellular Proteomics Cell Deconstruction System Reconstruction Series: Subcellular Biochemistry , Vol. 43, Chapter 10, pp 209-235.
Kremer H, van Wijk E, T. Märker, Wolfrum U, Roepman R (2006) Usher syndrome: molecular links of pathogenesis, proteins and pathways. Hum Mol Genet 15 Suppl 2: R262-70.
Park JH, Pulvermüller A, Scheerer P, Rausch S, Gießl A, Höhne W, Wolfrum U, Hofmann K P, Ernst O P, Choe H-W, Krauß N (2006) Insights into functional aspects of centrins from the structure of N-terminally extended mouse centrin 1. Vision Res 46:4568-4574.
Giessl A, Trojan P, Rausch S, Pulvermüller A, Wolfrum U (2006) Centrins, gatekeepers for the light-dependent translocation of transducin through the photoreceptor cell connecting cilium. Vision Res 46:4502-4509.
Reidel B, Orisme W, Goldmann T, Smith Clay W, Wolfrum U (2006) Photoreceptor vitality in organotypic cultures of mature vertebrate retinas validated by light-dependent molecular movements. Vision Res 46:4464-4471.
Reiners J*, Nagel-Wolfrum K*, Jürgens K, Märker T, Wolfrum U (2006) Molecular basis of human Usher syndrome: deciphering the meshes of the Usher protein network provides insights into the pathomechanisms of the Usher disease. Exp Eye Res 83:97-119 (*both authors contributed equally to the work).
Reiners J, Wolfrum U (2006) Molecular analysis of the supramolecular Usher protein complex in the retina: Harmonin as the key protein of the Usher syndrome. Adv Exp Med Biol 572:349-353.
van Wijk, Erwin, van der Zwaag B, Peters T, Zimmerman U, te Brinke H, Kersten FFJ , Märker T, Aller E, Hoefsloot LH , Cremers CWRJ, Cremers FPM , Wolfrum U, Knipper M, Roepman R, Kremer H (2006) The DFNB31 gene product whirlin connects to the Usher protein network in cochlea and retina by direct association with USH2A and VLGR1. Hum Mol Genet. 15:751-765.
Reiners J*, van Wijk E*, Märker T, Zimmermann U, Jürgens K, te Brinke H, Overlack, N, Roepman R, Knipper M, Kremer H, Wolfrum U (2005) Scaffold protein harmonin (USH1C) provides molecular links between Usher syndrome type 1 and type 2. Hum Mol Genet 14:3933-3943. (*both authors contributed equally to the work)
Bentmann A, Schmidt M, Reuss S, Wolfrum U, Hankeln T, Burmester T (2005) Divergent distribution in vascular and avascular mammalian retinae links neuroglobin to cellular respiration. J Biol Chem 280:20660-5.
Reiners J, Märker T, Jürgens K, Reidel B, Wolfrum U (2005) Photoreceptor expression of the Usher syndrome type 1 protein protocadherin 15 (USH1F) and its interaction with the scaffold protein harmonin (USH1C). Mol Vis 11:347-355.
Shu X, Fry, AM, Tulloch B, Manson FDC, Crabb JW, Khanna H, Faragher AJ, Lennon A, He S, Trojan P, Giessl A, Wolfrum U, Vervoort R, Swaroop A, Wright AF (2005) RPGR ORF15 isoform co-localizes with RPGRIP1 at centrioles and basal bodies and interacts with nucleophosmin. Hum Mol Genet 14:1183-1197.
Michel V*, Goodyear RJ*, Weil D, Marcotti W, Perfettini I, Wolfrum U, Kros CJ, Richardson GP#, Petit C# (2005) Cadherin 23 is a component of the transient lateral links in the developing hair bundles of cochlear sensory cells. Dev Biol 280:281-294 (*both authors contributed equally to the work; # shared senior authorship).
Adato A, Michel V, Kikkawa Y, Reiners J, Alagramam KN, Weil D, Yonekawa H, Wolfrum U, El-Amraoui A, Petit C (2005) Interactions in the network of Usher syndrome type 1 proteins. Hum Mol Genet 14:347-356.
Park JH, Krauss N, Pulvermüller A, Scheerer P, Höhne W, Giessl A, Wolfrum U, Hofmann KP, Ernst OP, Choe H-W (2005) Crystallization and preliminary X-ray studies of mouse centrin1. Acta Cryst F61:510-513.
Bytyqi AH, Lockridge O, Duysen E, Wang Y, Wolfrum U, Layer PG (2004) Impaired formation of the inner retina in an AChE knockout mouse results in degeneration of all photoreceptors. Europ J Neurosci 20:2953-2962.
Giessl A, Pulvermüller A, Trojan P, Park JK, Choe H-W, Ernst OP, Hofmann KP, Wolfrum U (2004) Differential expression and interaction with the visual G-protein transducin of centrin isoforms in mammalian photoreceptor cells. J Biol Chem 279:51472-51481.
Giessl A, Trojan P, Pulvermüller A, Wolfrum U (2004) Centrins, potential regulators of transducin translocation in photoreceptor cells. In: Williams DS (ed) Cell Biology and Related Disease of the Outer Retina. World Scientific Publishing Company Pte Ltd, Singapore. 195-222.
Wolfrum U, Reiners J (2004) Myosin VIIa in photoreceptor cell synapses may contribute to an Usher 1 protein complex in the retina. IOVS eLetters (May 26 2004)
Reiners J, Reidel B, El-Amraoui A, Boëda B, Huber I, Petit C, Wolfrum U (2003) Differential distribution of harmonin isoforms and their possible role in Usher 1 protein complexes in mammalian photoreceptor cells. Invest Ophthalmol Visual Sci 44:5006-5015.
Wolfrum U (2003) The cellular function of the Usher gene product myosin VIIa is specified by its ligands. Adv Exp Med Biol 533:133-42.
Wolfrum U (2003) Die Rolle der Apoptose bei Netzhautdegenerationen. Medgen 15:124-128.
Bode C, Wolfrum U (2003) Caspase-3 inhibitor reduces apoptotic photoreceptor cell death during inherited retinal degeneration in the tubby mouse. Mol Vis 9:144-150.
Schmidt M*, Giessl A*, Laufs T, Hankeln T, Wolfrum U, Burmester T (2003) How does the eye breathe? Evidence for neuroglobin-mediated oxygen supply of the vertebrate retina. J Biol Chem 278:1932-1935 (*both authors contributed equally to the work).
Boëda B, El-Amraoui A, Bahloul A, Goodyear R, Daviet L, Blanchard S, Perfettini I, Fath KR, Shorte S, Reiners J, Houdusse A, Legrain P, Wolfrum U, Richardson GP, Petit C (2002) Cadherin 23, harmonin, and myosin VIIa, three Usher I gene products that cooperate to shape the sensory hair cell bundle. EMBO J. 21:6689-6699.
Wolfrum U, Giessl A, Pulvermüller A (2002) Centrins in vertebrate photoreceptor cells. Adv Exp Med Biol 514:179-203.
Bolz H, Reiners J, Wolfrum U, Gal A (2002) The role of cadherins in Ca2+-mediated cell adhesion and inherited photoreceptor degeneration. Adv Exp Med Biol 514:399-410.
El-Amraoui A, Schonn J-S, Küssel-Andermann P, Blanchard S, Desnos C, Henry J-P, Wolfrum U, Darchen F, Petit C (2002) MyRIP, a novel Rab effector, enables myosin VIIA recruitement to melanosomes. EMBO Reports 3:463-470.
Pulvermüller A, Giessl A, Heck M, Wottrich R, Schmitt A, Ernst OP, Choe H-W, Hofmann KP, Wolfrum U (2002) Calcium dependent assembly of centrin/G-protein complex in photoreceptor cells. Mol Cell Biol 22:2194-2203.
Schmitt A, Wolfrum U (2001) Identification of novel molecular components of the photoreceptor connecting cilium by immunoscreens. Exp Eye Res 73:837-849.
Küssel-Andermann P, El-Amraoui A, Safieddine S, Nouaille S, Perfettini I, Lecuit M, Cossart P, Wolfrum U, Petit C (2000) Vezatin, a novel transmembrane protein, bridges myosin VIIA to the cadherin/catenin complex. EMBO J 19:6020-6029.
Wolfrum U, Schmitt A (2000) Rhodopsin transport in the membrane of the connecting cilium of mammalian photoreceptor cells. Cell Motil Cytoskeleton 46:95-107.
Remé CE*, Wolfrum U*, Imsand C, Hafezi F, Williams TP (1999) Photoreceptor autophagy: Effects of light-history on number and opsin content of degradative vacuoles. Invest Ophthalmol Visual Sci 40:2398-2404 (*both authors contributed equally to the work).
Körschen HG, Beyermann M, Müller F, Heck M, Vantler M, Koch KW, Kellner R, Wolfrum U, Bode C, Hofmann KP, Kaupp UB (1999) Interaction of glutamic acid-rich proteins with components of the cGMP-signaling pathway in rod photoreceptors. Nature 400:761-766.
Tai AW, Chuang J-Z, Bode C, Wolfrum U, Sung C-H (1999) Rhodopsin´s carboxy-terminal cytoplasmic tail acts as a membrane receptor for cytoplasmic dynein by binding the dynein light chain Tctex-1. Cell 97:877-887.
Wolfrum U, Schmitt A (1999) Evidence for myosin VIIa driven transport of rhodopsin in the plasma membrane of the photoreceptor-connecting cilium. In: Hollyfield JG, Andersson RE, LaVail M (eds) Retinal degeneration diseases and experimental therapy. Kluwer Academic / Plenum Publishers, New York. 3-14.
Wolfrum U, Liu XR, Schmitt A, Udovichenko IP, Williams DS (1998) Myosin VIIa as a common component of cilia and microvilli. Cell Motil Cytoskeleton 40:261-271.
Wolfrum U, Salisbury JL (1998) Expression of centrin isoforms in the mammalian retina. Exp Cell Res 242:10-17.
Liu X, Vansant G, Udovichenko I P, Wolfrum U, Williams DS (1997) Myosin VIIa, the product of the Usher 1B syndrome gene, is concentrated in the connecting cilia of rod and cone photoreceptor cells. Cell Motil Cytoskeleton 37:240-252.
Wolfrum U (1997) Cryofixation methods in biological electron microscopy - their limits. J Comp Assis Microscopy 9:73-76.
Wolfrum U (1997) Cytoskeletal elements in insect sensilla. J Insect Morphol & Embryol 26:191-203.
Huber A, Schulz S, Bentrop J, Groell C, Wolfrum U, Paulsen R (1997) Molecular cloning of Drosophila Rh6 rhodopsin: the visual pigment of a subset of R8 photoreceptor cells. FEBS Letters 406:6-10.
Huber A, Sander Ph, Wolfrum U, Groell C, Gerdon G, Paulsen R (1996) Isolation of genes encoding photoreceptor-specific proteins by immunoscreening with antibodies against purified blowfly rhabdomes. J Photochem Photobiol 35:69-76.
Wolfrum U (1995) Centrin in the photoreceptor cells of mammalian retinae. Cell Motil Cytoskeleton 32:55-64.
Huber A, Wolfrum U, Paulsen, R (1994) Opsin maturation and targeting to rhabdomeral photoreceptor membranes requires the retinal chromophore. Eur J Cell Biol 63:219-229.
Kaib M, Ziesmann J, Wolfrum U (1993) Modulation of odour-sensitivity by CO2 in a termite sensillum: A possible mechanism for signal interpretation. In: Wiese K, Gribakin FG, Popov AV, Renninger G (eds) Sensory systems of arthropods. Brinkhäuser, Basel. 481-488.
Wolfrum U (1992) Cytoskeletal elements in arthropod sensilla and mammalian photoreceptors. Biol Cell 76:373-381.
Wolfrum U (1991) Distribution of F-actin in the compound eye of Calliphora erythrocephala (Diptera, Insecta). Cell Tissue Res 263:399-403.
Wolfrum U (1991) Tropomyosin is co-localized with the actin filaments of the scolopale in insect sensilla. Cell Tissue Res 265:11-17.
Wolfrum U (1991) Centrin- and -actinin-like immunor.eactivity in the ciliary rootlets of insect sensilla. Cell Tissue Res 266:31-38.
Wolfrum U (1990) Actin filaments: the main components of the scolopale in insect sensilla. Cell Tissue Res 261:85-96.
Wolfrum U, Kaib M (1988) Kastenspezifisches Verhalten der Termite Schedorhinotermes lamanianus und dessen Beziehung zu Unterschieden in Ultrastruktur, Häufigkeit und Topographie antennaler Sensillen. Mitt dtsch Ges allg angew Ent 6:86-90.
